Is there a maximum dose. Sometimes I have to rinse three – four or five times to get relief.

An Isotonic solution is safe to use at least four times a day. But if=f you have to rinse five times a day for relief, you might try using a Hypertonic solution, which is a higher concentration solution. Some physicians recommend the hypertonic solution in certain cases because they believe it will draw the fluid and mucus out of congested nasal and sinus openings more effectively. It is recommended that you use a hypertonic solution only under the advice of your physician or by using careful judgment. If you experience any intolerable burning or stinging, please use the Isotonic solution. We feel that, apart from transient mild burning, the hypertonic solution will not cause any permanent damage when used a few times, as needed.