Your product has changed my life – thank you so much! How do I know if need the extra-large bottle? Posted on December 31, 2018March 8, 2023 by 0 Vote Up Vote Down Ask A Doctor Staff asked 4 years ago Your product has changed my life - thank you so much! How do I know if need the extra-large bottle? 1 Answers 0 Vote Up Vote Down Ask A Doctor Staff answered 4 years ago For 99% of the users, regular 8 oz. bottle is enough.� For patients with chronic rhino sinusitis, cystic fibrosis, certain immune disorders, post radiation therapy and many other cases, 16 oz, or 480 ml solution may be required. Please login or Register to submit your answer Username or Email Address Password Remember Me